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Exendin-4, a GLP-1R agonist, also suppressed basal expression of several inflammatory mediators and in combination with phosphodiesterase inhibitors, decreased CXCL10 expression by IFN- (a type II-interferon) in human islets and in MIN6 cells (a mouse -cell line)

Stuchlik A

Both medications can facilitate weight loss, but they have distinct mechanisms of action, degrees of effectiveness, risks, and side effects, says Daniel Maselli, M.D., a board-certified physician in obesity medicine